Naruto Shippuden Episode 300 blood is splattered on a terrified Tsunade as she excuses herself from the room. Seeking an explanation, Shizune tells the two of Tsunade's two great loves and loss which led up to her current state. Hearing this, the Raikage states that he would not have placed the lives of his subordinates in the hands of someone in that mental state, an indignant Shizune speaks out against his chastisement of her mistress, throwing the extracted exploding bug at his feet. The flashback ends with Naruto and B heading towards the battlefield while A and Tsunade return to headquarters.
As Tsunade and A escort Naruto and Killer Bee to the war, Tsunade questions of her Naruto Shippuden Episode 300 faith in Naruto. She remembers a time before she met Naruto when she crossed paths with A. A was in need her medical talents to save a wounded subordinate. This encounter ultimately led up to Tsunade agreeing to help only if A could best her in an arm wrestling match. A wins using his speed to his advantage. After seeing the state of the patient, Tsunade requires that they tell her what had happened.
Naruto Shippuden Episode 300 As she listens on to the events of A and his followers ambushed by a ninja group known as the Nokizaru, Tsunade realizes the nature of the insect as a bomb with another inside A. After explaining this and having A make a promise to her, Tsunade catches and destroys a bug which had been hovering near A for some time - unbeknownst to them that the Nokizaru had been using it as a method to spy on them. Preparing to operate, Tsunade has Shizune lead the surgery while she oversaw it. Though A initially protested, believing that Tsunade should perform the surgery, the Sannin allays his fears somewhat. As Shizune, aided by Amai begins the surgery,
While en route, Kakashi receives word that Sai had managed to seal one of the Seven Ninja Swordsmen of Naruto Shippuden Episode 300 the Mist. He later receives intel from headquarters on the ninja swordsmen before he rushes towards where he hears a commotion. Upon his arrival, he sees Jinpachi Munashi and Kushimaru Kuriarare, who are affronted that Kakashi was wielding the Kubikiribocho. As they begin to battle, the two reincarnated Kirigakure shinobi begin to mercilessly cut down one another in order to get to Kakashi. Kakashi is not alone for long as Might Guy comes to his side and together the two take on the swordsmen after Kakashi awakens a kunoichi, who had been knocked unconscious on the battlefield. After telling her to flee, the four begin to battle,
Naruto Shippuden Episode 300 and it ends up that Kakashi is left momentarily blinded by Jinpachi's explosion. Despite this, the two men press on, remembering a time they went on a mission together along with Rin. The two are eventually able to stave off the Kiri-nin's attack until Ran returns with the Sealing Team who promptly seal away Kushimaru and Jinpachi.
As Guy and Kakashi prepare to regroup their forces, they receive word that one of the units were engaged in battle Naruto Shippuden Episode 300 with Ameyuri Ringo and decide to head to that location. Elsewhere, Ameyuri merciless attacks the members of Yurui's unit. With Yurui dead and only a handful of members left, the new leader of the team Nurui decides that they should escape as they were no match for one of the Seven Ninja Swordsmen of the Mist. As they flee, Omoi who believes that they should stand and fight, gets into an argument with Nurui and Kayui tries to quell the argument, but, Omoi unable to take the coward's way out turns and prepares to face Ameyuri. Clashing with the kunoichi, Omoi is soon overpowered until Nurui and Kayui arrive and lure her away as Ameyuri notes that she always saved the best for last. The two shinobi are soon incapacitated by Ameyuri's attack, leaving Omoi to lure her away once again. Using her Lightning Release: Depth Charge once again, Ameyuri is shocked to see the ground beneath her give way as she and Omoi began to sink into quicksand. When the Third Division arrives in time to rescue Omoi, Ameyuri who had seemingly grown to like the young Cloud ninja, gives him the blade Fang as a parting gift.
Taking place in the aftermath of the Kage Summit, Team Kakashi is sent out on a mission by Tsunade to a location known as "The Hole" to investigate an incident where its people were killed. Regretting that she could not assign more people to the mission because of recent incidents elsewhere, the team sets out nonetheless. While there, they split up into two teams, with Yamato and Sai encountering officers from the neighboring Hacho Village where Shiseru and her team, after learning they are from Konoha shinobi, escort them to their village leader Disonasu. Elsewhere, Sakura and Naruto, who are at The Hole's water spring, encounter Kabuto Yakushi who reveals that the ninja he reanimated were behind the killing so he can use The Hole's waters to create a clone of the still living Hidan. As a fight ensues, between the two sides as Yamato and Sai rejoin with their team-mates, a flashback of the destruction of the village shows the reincarnated shinobi as the cause. The flashback ends with two young children, Leo and Miina, being rescued by their teacher Dokku and escaping with a few survivors.
Team Kakashi has their hands with Kabuto's Hidan clone and the reanimated Hayate Gekou as Naruto gets swallowed by a giant snake, but uses his Shadow Clones to escape while ingesting some of the snakes that were present in the pond . When Naruto surfaced, Kabuto retreats and leaves with his servants, using the reanimated Deidara as diversion, after revealing a village guard corpse in the snake's mouth. Meanwhile, Dokku takes care of the orphans, while Miina, due to trauma, became mute. After the attack, Naruto and Sakura join up with Shiseru, Yamato and Sai going with the rest of the guards. While Yamato and Sai investigate why Kabuto destroyed the village, Sakura and Naruto follow Shiseru to Dokku's house. When Dokku and the orphans see them and seeing Naruto wearing the same forehead protector as the reincarnated shinobi, Leo kicks Naruto and they run until they reach a broken bridge. Leo crosses first and when Dokku and Miina run, they fall down the ravine, but are saved by Naruto. Yamato and Sai ask about information when the nearby village leader showed them a book revealing the origin of The Hole, where Tonika Village resides. Some power resided on the hole many centuries ago. Naruto dreams again, this time inside his subconscious, in front of the Nine-Tails' cage, showing his feet oozing with the snakes he ingested earlier. Naruto and Dokku talk about the latter's failure to save a girl in his prime and all his failures in life, unlike Naruto, who became famous even in the Hacho Village, a rural area. Yamato and Sai discuss what will happen next, including "Saezuri" and an institution that will take care of the orphans. Elsewhere, with Hidan and Deidara nearby, Kabuto converses with some scrolls in a graveyard before putting another talisman in the reanimated Akatsuki member's head.